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ASOCompass: Context- and Chemistry-Aware Activity Prediction for Transferable Antisense Oligonucleotide Screening

Antisense oligonucleotide (ASO) activity is jointly influenced by nucleotide sequence, chemical modification, target-RNA context, dose, delivery protocol, and cellular environment.

  • ASO activity influenced by sequence, chemistry, context, dosage, delivery, and cellular environment
  • ASOCompass outperforms baseline across all distribution shifts and unseen targets

World

Rice brown spot resistance gene bsr1 also confers resistance to bacterial blight by suppressing sucrose efflux

Brown spot (BS), caused by the fungal pathogen Bipolaris oryzae, is a major disease threatening global rice production. However, the genetic basis of host BS resistance remains unclear.

  • Bsr1 gene provides resistance to brown spot and bacterial blight
  • Sucrose transporter gene suppresses sucrose efflux after pathogen attack
  • Near-isogenic line shows strain-specific resistance to bacterial blight

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Why Max Miller is staying in (for now)

Denounced on social media and by fellow Republicans, Ohio Rep. Max Miller is telling allies he's not quitting for a simple reason: It would be tantamount to admitting he beat his ex-wife and their child, which he denies.

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Fence of distrust

If policy implementation is too divisive or too drastic, President Prabowo Subianto may find that the fence of distrust grows even higher among the public, even as the physical ones come down.

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(EDITORIAL from The Korea Times on Aug. 7)

Korea is confronting a new reality. Record-breaking heat and prolonged drought a...

  • National strategy needed to address extreme heat crisis
  • Rising food prices due to heat devastation of agriculture
  • Energy security threatened by soaring electricity demand

World

'Tower Dump' Warrants Ruled Unconstitutional

alternative_right shares a report from The Hill: A federal judge in Mississippi ruled Wednesday that "tower dump" warrants are unconstitutional, declining to reverse a lower court decision refusing…

  • "Tower dump" warrants deemed unconstitutional by federal judge in Mississippi.
  • "Tower dump" refers to cellphone companies providing location data of all devices near a tower.
  • Judge Carlton Reeves cited Supreme Court's privacy protections for geofence warrants.

World

UK Drivers Take To Fuel Theft amid War-Driven Price Surge

Drivers in the United Kingdom have started filling up their tanks without paying for the fuel as driving costs surge on the fuel supply crunch driven by the war in the Middle East. The crimes include people driving off after filling up without paying and people claiming they cannot pay for the fuel they had acquired.

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