Developmental IL7/IL7R signaling in fetal resident tissue macrophages regulates adaptive responses to liver injury
Resident tissue macrophages (RTMs) originate from multiple fetal hematopoietic waves and seed organs during the prenatal window where they acquire tissue-specific homeostatic functions. Several growth factors within the fetal niche are required for RTM development, but knowledge of how these signals program tissue-specific RTM survival, identity, and function during the prenatal window is…
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