CityUHK researchers refine spatial omics techniques for clinical diagnostics
Scientists at City University of Hong Kong developed refined spatial omics mapping techniques to track molecular distributions within cellular structures for routine clinical tissue analysis applications
HONG KONG - A research team led by Professor Shi Peng from the Department of Biomedical Engineering at City University of Hong Kong (CityUHK) has developed Spectrum-FISH, a groundbreaking sequencing-free and amplification-free method for spatial analysis of tissue. This innovative approach utilizes a touch-and-go molecular fishing strategy with vertically aligned nanoprobes to preserve spatial information in freshly prepared tissue samples.
The study, published in Nature Biomedical Engineering, demonstrates how Spectrum-FISH can make spatial profiling more accessible, affordable, and scalable while maintaining biologically informative resolution. By minimizing tissue processing and reducing assay costs, Spectrum-FISH offers a viable pathway towards clinical translation of spatial omics.
The research was inspired by the need to balance the deepening understanding of complex biological systems through spatial omics technologies with the practical considerations of real-world clinical applications.
Written by urgent.news from Vietnam Investment Review's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
