BindCORE: Biophysical Ensemble Learning for Predicting Interaction Sites in Intrinsically Disordered Regions
Intrinsically disordered proteins and regions (IDPs/IDRs) mediate diverse cellular functions through binding segments whose functional properties are encoded in dynamic conformational ensembles rather than a single static state. Existing predictors of linear interacting peptides (LIPs) and molecular recognition features (MoRFs) rely primarily on sequence-derived features, leaving ensemble-level…
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