Zura Bio’s tibulizumab fails phase 2 trial for skin disease

Zura Bio's Phase 2 trial for tibulizumab in treating hidradenitis suppurativa has failed to meet its primary endpoint, according to a press release. The trial, which enrolled 247 participants, did not show a statistically significant difference in the reduction of abscess and inflammatory nodule count between the tibulizumab treatment groups and the placebo group.

Despite this setback, the company's safety profile of tibulizumab was found to be consistent with inhibition of IL-17 and BAFF. Zura Bio will discontinue development of tibulizumab for this skin disease but will continue trials in systemic sclerosis and polymyalgia rheumatica.

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