MaaD-TAD: an all-atom model of the duplicated PRAMEF/HNRNPCL chromatin domain built from sequence homology
In the nucleus, the placement of genes in the 3D fold of DNA affects how they function. Models of this fold use two kinds of data: contact maps constructed from Hi-C, and nucleosome maps showing where DNA is wound around nucleosomes. Over evolution, sections of the genome were copied, creating near-identical regions. Reads from these regions cannot be assigned to one copy and are discarded,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
