BCAS3 regulates WIPI2b via a direct interaction in the ATG16L1-binding cleft
De novo formation of the phagophore membrane is a fundamental step in autophagy and relies on recruitment of the E3-like ligase complex via an interaction between ATG16L1 and phosphatidylinositol 3-phosphate (PtdIns3P)-effector protein, WIPI2b. Although WIPI2b can directly bind membranes, how its membrane association is regulated is still not fully understood. Here, we describe BCAS3 as a novel…
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