Prevention of prion disease symptoms in mice with deep PrP lowering
PrP lowering slows prion disease in animal models, but prevention of symptoms by a therapeutic has never been demonstrated. A highly potent PrP-lowering C16-conjugated siRNA delivered into the cerebrospinal fluid (CSF) of mice lowers PrP to 12% residual in whole brain hemispheres. Early chronic treatment keeps prion-infected animals free from symptoms through 500 days post-inoculation,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
