Ultrasound waves that jiggle deep brain structures may relieve delusions in schizophrenia, small trial hints

A pilot study has shown promising results in using ultrasound waves to potentially reduce delusions in individuals with schizophrenia or related disorders. Delusions, which are false beliefs that are difficult to shake, can significantly impact the quality of life for those affected by these mental health conditions. The study involved 10 patients who underwent a 10-minute session of transcranial ultrasound stimulation, during which targeted ultrasound waves were delivered to a specific brain region called the globus pallidus internus.

This particular brain network has been suggested to play a role in schizophrenia symptoms, although the exact relationship between this network and the disorder remains unclear. The researchers conducted the trial in a randomized manner, with each participant receiving both the ultrasound treatment and a placebo treatment, spaced one week apart.

After each treatment, the participants were surveyed about the severity of their delusions and the associated stress. The ultrasound therapy was associated with less-severe delusions over the following week compared to the placebo treatment, although there were no significant changes in auditory hallucinations or overall cognition.

The side effects of the ultrasound treatment were mild and included fatigue and headaches. The researchers are optimistic about the potential therapeutic benefits of this targeted approach, but they emphasize that the current findings are still preliminary and require further verification in larger trials.