Development and pharmacological characterization of a stable HEK293 cell model for the study of human FLT3 signaling and its pharmacological modulation
Transient transfection in adherent cell lines has been used to study the function and pharmacology of the receptor tyrosine kinase FLT3, which is involved in myeloid leukemia and pain. However, transiently transfected cells express high levels of receptors, which show ligand-independent constitutive activity. We generated a stable recombinant cell line by transfecting a plasmid construct…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
