Researchers identify key pathway that drives T-cell exhaustion in cancer immunotherapy
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.
A team of researchers at UCLA Health Jonsson Comprehensive Cancer Center has discovered a crucial molecular pathway that leads to T-cell exhaustion in cancer-fighting immune cells. This finding, published in the journal Cancer Immunology Research, could potentially lead to the development of longer-lasting immunotherapies for solid tumors, such as CAR T-cell therapies and other forms of adoptive cell therapy.
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