Virtual Brain Modelling Reveals Altered Network Dynamics and Predicts Symptom Severity in Schizophrenia: Relevance to Antipsychotic Treatment Response and Resistance.
Background: Schizophrenia (SZ) is a heterogeneous disorder characterized by positive, negative, cognitive and disorganisation symptoms, with pleomorphic phenotype and poorly understood aetiology. Dopamine dysregulation represents the most replicated in vivo pathophysiology finding. However, accumulating evidence suggests altered large-scale brain connectivity and excitation/inhibition balance…
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