Resolution of chromosomal structural variation and vanA plasmid dynamics by nanopore-only sequencing across successive waves of a hospital outbreak of vancomycin-resistant Enterococcus faecium
Allele-based typing may incompletely resolve vancomycin-resistant Enterococcus faecium (VREfm) outbreaks in clinical laboratories because it can miss chromosomal structural variation and resistance plasmid dynamics. We evaluated a nanopore-only sequencing workflow in 68 VREfm isolates collected during a single-hospital outbreak predominantly involving Bezdicek multilocus sequence typing (MLST)…
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