Unified Network Spectroscopy: Inferring Reduced Biological Dynamics from Fluctuations under Structured Noise and Broken Ergodicity
Mechanistic models of biological networks predict but cannot be calibrated at scale, while learned representations describe but expose no dynamical operator. Both lack an inverse step mapping data onto the few dynamical quantities the data determine. We develop Unified Network Spectroscopy (UNS) as that operator and establish when it is well posed. Reading fluctuations about a physiological…
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