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Mutation-biased adaptation: The Yampolsky-Stoltzfus model revisited

The Yampolsky-Stoltzfus (YS) model provided the first formal demonstration that a bias in the introduction of new mutations can shape the direction of adaptive evolution, even when mutation rates are small relative to selection coefficients. Despite its foundational role, the model has been characterized almost entirely by simulation and closed-form solutions for its central quantity, the…

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