DNA replication stress redistributes the histone methyltransferase G9a and activates lineage-specific gene expression
Perturbations that cause DNA replication stress can induce lineage-specific changes in gene expression. Specifically, DNA replication stress activates primed loci in euchromatin that are epigenetically silenced, but the mechanism linking stalled replication forks to the activation of distal genes remains unknown. Using reactivation of fetal hemoglobin (HbF) by hydroxyurea in erythroid progenitors…
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