Disentangling the Crabtree and Warburg effects across syngeneic non-tumor and tumor cells.
Oxidative phosphorylation (OxPhos) and substrate-level phosphorylation (SLP) are the primary biochemical mechanisms for ATP generation in mammalian cells. Increased dependency on SLP can arise from either transient (e.g., Crabtree effect) or chronic (e.g., Warburg effect) suppression of OxPhos. We evaluated the steady-state bioenergetics of quiescent and proliferating mouse cells matched in…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
