A ribosomal pseudouridine drives an oncogenic translation program
Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with shared encoded features remains unclear. Here we show that SNORA81-guided pseudouridylation at U4636 controls a selective translational program in ovarian cancer cells. U4636 is…
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