Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion
Host shutoff is a conserved viral strategy to dismantle cellular defenses, yet the molecular orchestrators in large DNA viruses remain poorly defined. Through a systematic functional screen of the monkeypox virus (MPXV) proteome, we identify M2 as a potent, multifunctional effector that executes a global blockade of host gene expression. Unlike its assembly-centric homologs across the…
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