Microglia sculpt dopamine receptor-mediated adolescent behaviors in a social experience dependent manner

Adverse childhood experiences like social isolation (SI) contribute to long term negative health outcomes and the development of severe psychiatric disorder. Adolescence is a unique period of coordinated social and motivational system development driven by dopamine (DA) signaling. Microglia, immune cells of the brain, may play a unique role in regulating SI-induced DA system changes and…

biorxiv.org ·1d ago

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