Integrated immunopeptidomics and transcriptomics reveal a cancer-restricted non-canonical HLA class I ligandome in medulloblastoma
Medulloblastoma is the leading type of malignant brain tumor in children. Despite recent advances in T cell-based immunotherapy, the low mutational burden of medulloblastoma poses a considerable challenge to the discovery of mutation-derived neoantigens. Previous studies of medulloblastoma have investigated tumor-associated antigens and neoantigens derived from aberrant splice junctions. The…
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