Substrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the fate of HCHO has remained unclear. We report cryo-EM structures of TDM in apo, substrate-, and product-bound states that reveal a previously unknown…
The Victorian Ambulance Union says it has found out about a government plan to make paramedics the first responders to mental health call-outs through the media.
A drug recovery programme in the Northern Mariana Islands says it is seeing more severe withdrawal symptoms among some methamphetamine users than in the past.
The World Health Organization said on Friday that the Ebola outbreak caused by the Bundibugyo virus in the Democratic Republic of the Congo has spread to two additional health zones, bringing the…
