Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts
Accumulation of proteins such as amyloid beta (Abeta), hyperphosphorylated tau and alpha-synuclein within the brain alters neural information processing and causes neurodegeneration(1-3), but how toxic solutes are cleared from the brain remains highly controversial(4,5). Proposed exit routes include efflux across endothelial cells into the blood(6,7), and movement to the pial surface via…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
