An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss
Proceedings of the National Academy of Sciences, Volume 123, Issue 40, October 2026. SignificanceCurrent antiobesity therapies reduce body weight but often induce loss of lean mass and fail to achieve durable metabolic improvements after treatment ends. We show that an adipose-targeted RNA therapeutic targeting ZFP423, a transcriptional ...
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