Y Chromosome Loss Linked to Early Cancer Risk in Men
A study led by Dr Dan Theodorescu at the University of Arizona Cancer Center has found that loss of the … Read More The post Y Chromosome Loss Linked to Early Cancer Risk in Men appeared first on ProPakistani .
Research led by Dr Dan Theodorescu at the University of Arizona Cancer Center indicates that loss of the Y chromosome in men's body tissue may contribute to the formation of cancer. Published in JCI Insights, the study reveals that age-related Y chromosome loss can create a hidden genetic vulnerability in normal tissue, facilitating cancer growth.
Each male cell typically contains one X and one Y chromosome; however, the study found Y chromosome loss in seemingly healthy tissue adjacent to tumors, suggesting this could be an early indicator of cancer development. The researchers analyzed 1,000 tissue samples from 405 men across 11 major organs, employing automated fluorescent imaging to examine over 4.3 million cell nuclei and determine the ratio of Y to X chromosomes.
In bladder tissue samples obtained during cancer surgery, the study observed that Y chromosome loss progressed from normal tissue to early abnormal cells and eventually to cancer, with the highest loss rates observed in colon, rectum, esophagus, pancreas, and lung cancers. The researchers concluded that the proximity of the tissue to cancer correlated with greater Y chromosome loss.
Dr Theodorescu believes these findings could help physicians detect potential cancer in biopsy samples that might otherwise miss smaller tumors. He also suggests the discovery could enhance our understanding of cancer development and the relationship between Y chromosome loss and increased mortality from certain types of cancer.
Written by urgent.news from ProPakistani's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
