Thymic age and peripheral residence time determine antitumor competence of CD8+ T cells

Proceedings of the National Academy of Sciences, Volume 123, Issue 39, September 2026. SignificanceDevelopmental timing imprints durable functional programs in T cells, but how these programs shape antitumor immunity remains unclear. Using a time-stamp fate mapping model, we tracked CD8+T cells generated at different life stages in the ...

pnas.org ·2026-09-21

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