High-Grade Glioma Biology Varies by Age and Sex, Revealing Potential Treatment Targets
Researchers carrying out multiomics analyses of tumors from high-grade glioma patients found distinct molecular profiles and survival outcomes in different age groups and according to sex, and identified candidate treatment targets and potential prognostic markers. The post High-Grade Glioma Biology Varies by Age and Sex, Revealing Potential Treatment Targets appeared first on GEN - Genetic…
Researchers from the Icahn School of Medicine at Mount Sinai and collaborators have uncovered distinct biology and treatment targets for high-grade glioma (HGG) in children, adolescents, and young adults (AYA). The study, published in Cell Reports Medicine, identified age-dependent tumor biology and female-male differences, potentially guiding personalized treatment strategies.
Using proteogenomic analyses of tumors from over 100 HGG patients aged 0–40 years, the team found two AYA age groups with different molecular profiles and survival outcomes. Kinases such as CDK8, ATM, ATR, and LCK were identified as potential treatment targets, with CDK8 emerging as a promising candidate due to its role in suppressing oxidative phosphorylation, a key energy-producing process linked to better survival.
The researchers concluded that age and developmental context shape tumor biology, distinguishing tumor-related features from those associated with a patient's developmental stage.
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