Integrated gene-catalog and genome-resolved metagenomics reveal taxonomic and metabolic differences in the gut microbiome in irritable bowel syndrome
Background: Irritable bowel syndrome is a common gastrointestinal disorder with heterogeneous symptoms and incompletely understood pathophysiology. Gut microbiome dysbiosis has been repeatedly associated with IBS, but the extent to which taxonomic changes are accompanied by gene-level and genome-resolved differences in microbial functional potential and inferred microbial community structure…
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