More accurate risk assessment developed for Alzheimer's disease among nonwhite patients
Late-onset Alzheimer's disease (AD) is a progressive disorder characterized by cognitive decline and memory impairment, affecting an estimated 6.9 million people in the U.S. The clinical course of AD unfolds over many years, often beginning with subtle cognitive changes before progressing to overt dementia. Although the rate of decline varies among individuals, growing evidence suggests that…
A new multi-ancestry polygenic risk score (PRS) for Alzheimer's disease (AD) has been developed and validated, offering improved risk prediction for genetically diverse populations. The study, published in Nature Genetics, utilized summary information from genetic markers across the genome derived from over 63,000 AD cases and 484,000 age-matched controls.
The multi-ancestry PRS was tested in independent ancestrally diverse samples and validated in another group of mixed ancestry, including African American, Hispanic, and East Asian populations. Compared to previously developed PRSs based on European ancestry, the new multi-ancestry PRS demonstrated better predictive accuracy for AD in all populations examined, particularly for African American, Hispanic, and East Asian individuals.
This development addresses a critical challenge in the application of PRS, as previous models have been underrepresented in genetic association studies involving diverse ancestries.
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