JNCASR scientists develop smartphone-based diagnostic system for detection of Alzheimer’s disease
Scientists at the Jawaharlal Nehru Centre for Advanced Scientific Research have created a low-cost, smartphone-enabled diagnostic system for early detection of Alzheimer's disease. The system detects Alzheimer's biomarker amyloid-β (Aβ) using a tiny molecule that changes fluorescence intensity upon interaction with Aβ fibrils. Fluorescence lifetime imaging microscopy is used to robustly detect biomarkers and enhance diagnostic precision.
The platform, called ADxFluor, combines dual-mode brain imaging, biofluid detection, and smartphone-based quantification of Aβ in biofluids. This innovative approach offers a simple, sensitive, and scalable solution for early and accurate Aβ detection, making it a promising foundation for next-generation smart diagnostics of Alzheimer's and other neurodegenerative diseases.
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