Programmable Recruitment of RNA-Binding Proteins Enables Small Molecule-Directed Destabilization of Nuclear Pre-mRNA

Chemically induced proximity has not been systematically applied to control RNA fate. Here, a programmable platform was developed to identify RNA-binding proteins (RBPs) that can be recruited by small molecules to destabilize RNA. Using microtubule-associated protein Tau (MAPT) pre-mRNA as a model target, a heterobifunctional molecule was designed to bind both a ligandable structure in MAPT…

biorxiv.org ·18h ago

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Intelligent people tend to perform better at school and at work, as numerous studies have shown. But what happens in domains where incentives such as good grades or financial rewards don't apply and where socioeconomic status is not a significant factor? Wine knowledge is a case in point.

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Scientists Reconstruct Sound of Jurassic Insects

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18h ago ·sci.news

Musk's SpaceX to build $100bn launch site in Louisiana

The project - named Starbase - will be the firm's biggest facility yet and aims to send rockets to space in 2029.

17h ago ·bbc.co.uk

Musk's SpaceX to build $100bn launch site in Louisiana

The project - named Starbase - will be the firm's biggest facility yet and aims to send rockets to space in 2029.

17h ago ·bbc.co.uk

Strong oyster reefs start with genetic diversity

The European flat oyster (Ostrea edulis) was once widespread but has now become so scarce in the North Sea that it no longer forms ecologically functioning reefs. Along with the demise of the flat oyster, the three-dimensional structures that provide habitat for more than 100 marine species have disappeared.

17h ago ·phys.org