Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes
While thousands of cis expression quantitative trait loci (cis-eQTLs) have been reliably identified, detecting trans-eQTL effects has proven to be challenging due to insufficient statistical power, lack of comparable tissues and cohorts, and low reproducibility across studies. Here, we present Trex-QTL, a novel trans-eQTL detection method that models eQTL summary statistics as a mixture…
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