Spatial microRNA profiling at single-cell resolution by in situ barcoded extension

The spatial organization of post-transcriptional regulation is a fundamental yet difficult to access layer of tissue biology. MicroRNAs (miRNAs) are small RNAs with a key role in post-transcriptional regulation, but their short length has excluded them from spatial profiling technologies, leaving them largely unexplored in spatial transcriptomics. Here, we introduce miR-Space, a method that…

biorxiv.org ·1d ago

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