SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics

High-resolution sequencing-based spatial transcriptomics, including Stereo-seq and Visium HD, aggregates dense capture units into cell-resolved expression matrices. During tissue processing and permeabilization, RNA released from source cells can spread to neighbouring capture locations, reducing cell-type specificity and biasing downstream analyses. Here we developed SPARKLE (Spatial Ambient RNA…

biorxiv.org ·1d ago

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

More in Science

‘Ashoka-era stupa, bigger than Sanchi’: 90 years on, Ujjain mound comes under renewed focus

1d ago ·indianexpress.com

‘Ashoka-era stupa, bigger than Sanchi’: 90 years on, Ujjain mound comes under renewed focus

1d ago ·indianexpress.com

IIM Indore Study Finds ‘Good Enough’ Decisions Can Reduce Uncertainty In Short-Term Projects

Indore (Madhya Pradesh): In a finding that could reshape how managers make decisions in uncertain and rapidly changing business environments, a new study by Indian Institute of Management Indore has found that choosing a “good enough” solution rather than constantly pursuing the optimal one can substantially reduce uncertainty…

1d ago ·freepressjournal.in

Flightless beetles evolved distinct snail-hunting shapes on Japan's largest island

Islands are widely recognized as natural laboratories of evolution. The ocean restricts movement among islands, allowing isolated populations to adapt to different environments and, at times, diverge into new species.

1d ago ·phys.org

Australia needs more people who think like scientists. Here’s what that means

Science equips us with the tools to reason, evaluate evidence, and make informed decisions in a complex, changing world.

Individuals who think like scientists have curiosity and reasoning skills.
Australia faces shortage of science students, limiting potential applications.
Early science education fosters diverse career opportunities in various industries.

1d ago ·theconversation.com

Scientists map the microscopic roots of chaos in dusty plasma using supercomputer simulations

Research Matters Staff Writer(s) Jammu 17 Aug 2026 Researchers have achieved a breakthrough in understanding the chaotic world of turbulence by tracking the movement of millions of individual particles in a specialised state of matter known as dusty plasma.

Scientists map microscopic origins of turbulence in dusty plasma using supercomputer simulations.
Understanding dusty plasma turbulence could improve plasma containment in nuclear fusion reactors.

1d ago ·researchmatters.in