HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

Regulatory T (Treg) cells expressing RORgamma-t accumulate in the intestinal mucosa, yet the signals that determine whether they remain suppressive or acquire inflammatory features are incompletely defined. We first reanalyzed human ileal single-cell data and identified Crohn's disease-enriched FOXP3+ states in which RORC, HIF1A, hypoxia-responsive, inflammatory, and metabolic programs converged.…

biorxiv.org ·17h ago

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