FluoroFate: A generalisable platform for time-resolved single-cell analysis of cell fate enables quantification of cell death dynamics

Fundamental cellular decisions of life and death are governed by intricate and tightly regulated intracellular signalling pathways that determine whether cells proliferate, enter quiescence, or undergo programmed cell death (apoptosis). Live-cell fluorescence imaging enables these processes to be observed in real time at single-cell resolution, but two problems limit their study. First, existing…

biorxiv.org ·23h ago

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