Dysregulation of the SARA-Smurf2 Regulatory Axis in Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) is associated with dysregulation of transforming growth factor {beta} ; (TGF{beta}) signaling, a key contributor to epileptogenesis. SARA (Smad Anchor for Receptor Activation), a central regulator of this pathway, is controlled by the E3 ubiquitin ligase Smurf2 through ubiquitination. However, the role of the SARA--Smurf2 axis in regulating TGF{beta} signaling during…

biorxiv.org ·12h ago

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