Decoding single-cell replication states from imaging data reveals locus-specific subnuclear position dependencies of replication initiation

Replication timing (RT) is a fundamental feature of genome regulation, tightly linked to chromatin state and three-dimensional (3D) nuclear organization. Yet how the reproducible population-level timing program emerges from stochastic replication decisions in individual cells remains unclear, because it requires measuring RT and 3D genome organization jointly in the same cell. Here, we introduce…

biorxiv.org ·1d ago

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