A stimulus-state geometry in somatosensory cortex reorganizes during inflammatory pain

Adaptive behavior requires external input to be interpreted together with internal state and ongoing behavior. During pain, noxious somatosensory input evokes movement and arousal, and injury reshapes this relationship, yet how cortical activity organizes stimulus content with behavioral state remains unclear. In awake mice, we delivered hindpaw stimuli while tracking movement, arousal and facial…

biorxiv.org ·21h ago

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