Network Topology reveals disrupted AMPA receptor stabilization leads to an impaired LTD in epileptic synapses
Cognitive comorbidities in epilepsy patients may be the result of synaptic alterations and impaired synaptic signalling. Electrophysiological evidence demonstrates that epileptic synapses undergo a GluN2B-dependent metaplastic shift, where a low-frequency stimulation protocol unexpectedly induced long-term potentiation (LTP) rather than long-term depression (LTD). However, the downstream…
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