Hepatic estrogen receptor α is required for stage specific coupling of liver metabolism and proliferation during pregnancy
Background and Aims: Pregnancy requires dynamic, stage-specific adaptations in maternal liver metabolism and growth to sustain fetal development while preserving systemic homeostasis. Estrogen signaling, which significantly increases during pregnancy, is primarily mediated in hepatocytes by estrogen receptor (ER). Although hepatic ER regulates female liver metabolism under non-pregnant…
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