Long-term risk of cardiovascular disease after assisted reproductive technology and infertility: A cohort study
by Angelo Giosuè Mezzoiuso, Peter Henriksson, Márta Radó, Kenny A. Rodriguez-Wallberg, Anna Sara Oberg Background The use of Assisted Reproductive Technology (ART) is increasing worldwide. These treatments involve ovarian stimulation to enable multiple follicle recruitment, hence inducing supraphysiological estrogen levels. While most long-term follow-up of women undergoing ART has concerned…
A long-term study published in Sweden has examined the potential cardiovascular risks associated with Assisted Reproductive Technology (ART) and infertility. Researchers analyzed data from 380,756 women who first gave birth between 1992 and 2002, comparing those who conceived using ART with those who did not, while adjusting for factors such as age, body mass index, and pre-existing conditions.
While ART was not linked to an increased risk of most cardiovascular diseases, women who underwent ART exhibited a higher risk of cerebral ischemic conditions, with a 30-year risk ratio of 1.44. However, women with a history of infertility generally showed elevated risks for various cardiovascular and metabolic diseases, though some of these elevated risks were explained by differences in baseline characteristics.
The study highlights the importance of considering infertility as a potential marker for cardiovascular and metabolic health in women.
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