Three proteins help organs tailor shared circadian clock to their individual needs, mouse study finds
LMU researchers have elucidated how different organs adapt the same clock machinery to regulate their individual needs over the course of a day.
Three proteins – PROX1, HNF1B, and HOXA5 – play a critical role in helping organs fine-tune a shared circadian clock to meet their unique needs, according to a study published in Nature Cell Biology. Researchers from LMU University discovered that these cell-identity transcription factors interact with the clock machinery CLOCK and BMAL1 in liver, kidney, and lung cells, aligning daily clock output with each organ's specific physiology.
The findings could lead to more targeted therapies for conditions linked to circadian disruption, such as cardiovascular disease and diabetes.
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