Brain wiring patterns of SuperAgers may help flag Alzheimer’s risk years before symptoms
A brain network pattern that separates older adults with exceptionally sharp memory from people with Alzheimer’s disease may also flag hidden risk in healthy seniors, according to a study published in Science Advances. Cognitively healthy older adults whose brain activity resembled the Alzheimer’s pattern scored similarly on memory tests at first but later tended to […]
A recent study published in Science Advances suggests that brain wiring patterns may help identify individuals at risk for Alzheimer's disease years before symptoms appear. The research, led by Kanhao Zhao and Yu Zhang from the Stanford University School of Medicine, focused on mapping the functional connectome, or the web of coordinated activity linking regions across the brain, using resting-state functional MRI scans.
By contrasting SuperAgers, who maintain exceptional memory well into older age, with Alzheimer's patients, the study discovered that cognitively healthy adults whose brain activity patterns resembled those of Alzheimer's patients tended to experience faster memory decline, higher accumulation of Alzheimer's-related plaques, and a higher likelihood of progressing to mild cognitive impairment or dementia.
This discovery could potentially aid in early intervention and prevention strategies for Alzheimer's disease.
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