Cardinals vs. Rams odds: Opening lines for Week 10 matchup

As the 2026 NFL season enters week 10, the Arizona Cardinals find themselves at home facing the Los Angeles Rams. According to FanDuel Sportsbook, the Cardinals are significant underdogs in this matchup, with the Rams opening as 7.5-point favorites. This large spread raises the question of whether the Rams can even make the game competitive.

While the Cardinals had a disappointing performance against the Seahawks last week, they now take on a Rams team that has allowed four sacks in their last game against the Washington Commanders. The 7.5-point spread may seem substantial, particularly in a home game against a 5-4 Rams squad that hasn't met expectations this season, and lost to the Cardinals in their previous matchup. Despite the unfavorable odds, this line seems both interesting and reasonable.