A little-known protein could be a major culprit in type 2 diabetes
Scientists have discovered that a buildup of a protein called Miro1 may be a hidden driver of insulin resistance in Type 2 diabetes, with preclinical experiments showing that removing it restores the muscles’ response to insulin. Exercise was also found to lower Miro1 levels in people with diabetes, revealing a potential new pathway for treating the disease.
A protein called Miro1 may be a significant cause of insulin resistance in Type 2 diabetes, according to researchers. Miro1 is found in higher levels in the skeletal muscles of people with the disease. When scientists removed Miro1 in preclinical models, insulin responsiveness was restored. Additionally, exercise was found to lower Miro1 levels in people with Type 2 diabetes, suggesting physical activity may improve insulin sensitivity by reducing the protein.
The research, published in Nature Communications, could lead to new treatments that target Miro1 to help manage insulin resistance, a key factor in Type 2 diabetes.
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