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Uncovering disease progression trajectories across multiple timescales with hybrid ODE-mixture models

Biological systems are capable of evolving across multiple timescales, yet most modeling approaches capture either short-term physiological responses or long-term disease progression. Additionally, methods that combine these time scales either struggle with inter-individual variation, or require large volumes of data to work. We present Latent Class Parameter Trajectory Analysis (LCPTA), a hybrid…

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