Structure of Bacillus cereus ZmaM, a peptidase-ABC transporter that secretes and activates zwittermicin A
Bacteria engage in microbial warfare by secreting toxic molecules. These toxins can serve as therapeutics or drug discovery starting points, motivating investigations of their production. Bacteria that produce these toxins must protect themselves, and a common strategy is to synthesize an inactive prodrug that is activated upon secretion. Some prodrugs are capped with N-acyl-[x1D05]-asparagine…
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