Strategies of mechanical adaptations of circulating tumor cells and properties of their cellular microenvironment have predictive and prognostic biomarker value
Mechanically demanding conditions in the blood circulation damage and kill majority of tumor-shed circulating tumor cells (CTCs). Mechanical fitness: a set of mechanical properties detected with atomic force spectroscopy based force spectrometry supports survival of CTCs. We propose that live CTCs isolated from peripheral blood of prostate cancer patients represent distinct strategies of fitness…
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