Revamped transposon-induced hepatocellular carcinoma model reveals deep similarities of cancer-driver landscapes across mice and humans

Genome-scale cancer-driver discovery is limited by statistical uncertainty in driver calling and by experimental constraints on mutations available for selection. We developed 3xfOnc3 - a three-frame Sleeping Beauty (SB) mutagenesis system designed to broaden functional perturbations and reduce integration biases of traditional SB screens - and tested it in vivo in mouse liver. Within 12 months,…

biorxiv.org ·1d ago

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

More in Health & Medicine

LASG procures HIV drug for over 147,000 patients

The Lagos State Government has said it has begun procuring antiretroviral drugs with state funds to sustain HIV treatment, noting that 147,904 people living with the virus receive medication across…

1d ago ·punchng.com

General : REE Policy, Obesity Treatment And VMY 2026 Achievements Focus Of Dewan Rakyat Today

KUALA LUMPUR, Nov 2 (Bernama) -- The Dewan Rakyat sitting today will look into the status of the rare earth element (REE) industry policy, updates on obesity and diabetes treatment involving GLP-1 RA…

1d ago ·bernama.com

Watch out for these warning signs of seasonal affective disorder

Feeling fatigued, less energetic, craving heavy foods? It could be a sign of the depressive disorder

1d ago ·torontosun.com

Will losing US midterms see Trump double down or signal beginning of the end?

Tuesday’s US midterm election is both hugely consequential and not so consequential even as the world waits to see the American voters’ verdict on Donald Trump’s presidency – and the impact that…

1d ago ·scmp.com

FBR marks senior citizen pensioner’s tax status as ‘In-Active’

ISLAMABAD: A senior citizen taxpayer deriving income from bahbood/pensioner certificate was declared “In-Active” on November 1, 2026 by the Federal Board of Revenue (FBR) forcing the taxpayer to…

1d ago ·brecorder.com

Diagnosing dark sprite edges: a practical alpha compositing check

A transparent character can look correct in an image viewer yet acquire a dark fringe in a game. Before changing the artwork, check whether the image data and renderer agree about alpha representation…

Verify alpha representation between image data and renderer to prevent darkened assets.
Compare partly transparent test image over black, white, and saturated backgrounds to isolate cause.

1d ago ·dev.to